Burgeoning evidence has indicated that normal autophagy is required for nuclear factor erythroid 2-related factor (Nrf2)-mediated cardiac protection whereas autophagy inhibition turns on Nrf2-mediated myocardial damage and dysfunction in a setting of pressure overload (PO).However, such a concept remains to be fully established by a careful genetic
BackgroundRheumatic heart disease (RHD) poses a major disease burden among disadvantaged populations globally.It results from acute rheumatic fever (ARF), a complication of Group A Streptococcal (GAS) infection.These conditions are acknowledged as diseases of poverty, however the role of specific social and environmental factors in GAS infection an
In this article, the author will try to explain the basic principles of the practical focus of using radar in maritime navigation, analysing its potential errors and limitations.An ah6789-001 attempt will also be made to describe the basic seamanship practice of how to set up the radar, determine the radar blind sectors, calculate the radar positio
With a high occurrence rate and high mortality, the treatment of colorectal cancer (CRC) is increasingly attracting the attention of scholars.Hub genes that determine the phenotypes of CRC become essential for targeted therapy.In the present study, the importance of cyclin-dependent kinases (CDKs) on the occurrence of CRC was identified by data min
Background Iranian government has introduced multiple healthcare system reforms during the last 30 years aiming at improving accessibility and affordability of care.Pharmaceutical products are one of the major sources of financial burden on the healthcare system.The healthcare system and pharmaceutical sector have been balanced sources iphone 90m o